I would highly recommend Julian May's Intervention, Saga of Pliocene Exile, and Galactic Milieu from the 80s-90s. These interrelated series stretch from the far past to our space-faring future and combine science fiction, technology, and fantasy into one grand vision. Intervention is my favorite and works very well as a stand alone novel... Ah, Oncle Rogi...
My other recommendation would be Octavia Butler's Xenogenesis (aka Lilith's Brood) from the late 80s, a series of novels with an interesting take on the future of humanity and what it means to be human. A bit less Sci-Fi, but also highly recommended, is her powerful Parable series from the 90s (Parable of the Sower, Parable of the Talents). In it she explores issues of race, freedom, religion, violence, and more through extrapolating a dark but all too possible vision of the future based on current trends in American society.